基本信息
•出生年月：1982年2月
•民族：汉族
•学科专业：药物化学
•研究方向：协同靶向药物发现；多功能前药设计；人工智能药物设计。
•邮箱：wq@mail.scuec.edu.cn
• ORCID：0000-0003-1935-2631
学习与工作经历
• 2000.09-2004.06，武汉大学药学院，药学专业，医学学士
• 2004.08-2009.12，山东大学药学院，药物化学专业，医学博士
• 2012.11-2013.11，佐治亚州立大学，化学系，访问学者
• 2010.01-2013.05，beat365官网药学院，讲师
• 2013.06-至今，beat365官网药学院，副教授
• 2019.03-2022.09，beat365官网药学院药学系党支部，支部书记
• 2020.09-2025.04，beat365官网药学院药学系，系主任
教研成果
[1]."药物-靶点相互作用"省级虚拟仿真实验，湖北省省级虚拟仿真实验项目，2019年，主持。
[2]."药物化学"省级线上线下混合式一流课程，湖北省省级一流本科课程，2023年，主持。
[3].《药物化学》课程思政教学项目，校级，2023年，主持。
[4].《药物化学》人工智能赋能课程，校级，2024年，主持。
[5].beat365官网创新指导优秀教师，2017年。
[6].beat365官网创新指导优秀教师，2019年。
[7].beat365官网第六届教学先进个人，2023年。
[8].高等教育出版社"十四五"医学规划新形态教材（药学系列）《药物化学》编委，2023年。
[9].指导学生完成大学生创新创业训练计划国家级创业训练项目1项，2019年。
[10]."药物化学课程群"教学团队获评校级基层教学组织，2019年。
科研成果
[1].基于碱性氨基酸骨架的氨肽酶N抑制剂的设计、合成及活性研究，国家自然科学基金青年科学基金项目（C类）（编号：21102185），2011年，主持。
[2].抗冠状病毒靶向先导化合物组合筛选，中央高校基本科研业务费专项资金自科一般项目，2020年，主持。
[3].真菌天然产物胰脂肪酶抑制剂Vibralactone的不对称合成、构效关系及作用机制研究，国家自然科学基金面上项目（编号：82574290），2026年，参与。
[4].蛇根草来源的新型选择性B淋巴细胞免疫抑制剂的构效关系和作用机制研究，国家自然科学基金面上项目（编号：81973208），2020年，参与。
[5].基于肿瘤细胞标记物MMP-2/CD13为靶标的抗癌先导结构的发现，国家自然科学基金重大研究计划（编号：90713041），2007年，参与。
[6].脯甘类肽特异性IV型胶原酶抑制剂的设计、合成与抗癌活性研究，国家自然科学基金面上项目（编号：30772654），2007年，参与。
[7].以金属蛋白酶为靶点的抗癌先导化合物的发现，国家科技部863专项研究课题（编号：2007AA02Z314），参与。
[8].基于功效导向的中药药效物质辨识关键技术及应用，湖北省科技进步二等奖，2022年，排序第5。
专利
[1].一类呋甾烷醇型甾体皂苷类化合物及其制备方法和用途，发明人：王强、杨光忠、陈玉、李雪妮、徐婧，授权公告号：CN 117069788 B。
[2].一类A环羟基全取代呋甾烷醇型甾体皂苷类化合物及其制备方法和用途，发明人：杨光忠、王强、陈玉、李雪妮、徐婧，授权公告号：CN 117603292 A。
[3].一种三叶青多糖保肝膨化食品及其制备方法，发明人：任永申、鄢连和、李竣、刘新桥、王强、梁帅、雷蕾，授权公告号：CN 109170592 A。
[4].碱性氨基酸类金属蛋白酶抑制剂及其应用，发明人：徐文方、方浩、牟佳佳、王强，授权公告号：CN 101481325A。
发表论文
[1] Xianghong Chen, Tian Gao, Qiang Wang, Yiyang Yuan, Chenyang Yu, Jun Li, Xianju Huang, Hui Xiong, Zhinan Mei, Guangzhong Yang, Yu Chen Structurally diverse clerodane diterpenoids with anti-inflammatory and anti-diabetic effects from Tinospora crispa (L.) Hook.f. & Thomson.Phytochemistry, 2026, 248, 114902.
[2] Yinuo Fu, Chenyang Yu, Yuxi Guo, Bowei Tang, Yongsheng Zheng, Guangzhong Yang, Qiang Wang Recent advances in HDAC-based multi-target inhibitors.Bioorganic Chemistry, 2026, 180, 110105.
[3] Qiang Wang, Ming Lan, Yuxi Guo, Yifan Li, Yongsheng Zheng Access to 5-Hydroxybenzofurans via Formal [3+1+1] Annulation of Quinone Esters with Pyridinium Ylides.ChemistrySelect, 2025, 10(30), e02526.
[4]余晨阳,唐渤唯,郭育禧,兰明,王强 基于生物信息学与计算机模拟技术的复方大蓟饮子治疗上消化道出血机制研究.中医临床研究, 2025, 17(23), 1-11.
[5]王强,兰明,骆玺,蒙涛,杨光忠,李竣 通过网络药理学探究宽筋藤治疗类风湿性关节炎的药理机制.beat365官网学报(自然科学版), 2025, 44(5), 616-628.
[6] Maoshuo Yang, Wei Zhao, Jinwei Zhang, Lanlan Liu, Sijia Tian, Yaqing Miao, Yongxin Jia, Limei Wang, Qipeng Chai, Qiang Wang, Fabao Liu, Yingjie Zhang, Xiaona You HDAC11 Inhibition as a Potential Therapeutic Strategy for AML: Target Identification, Lead Discovery, Antitumor Potency, and Mechanism Investigation.Journal of Medicinal Chemistry, 2025, 68(8), 8124-8142.
[7]骆玺,兰明,郭育禧,王强,郑永胜 联芳基轴手性化合物当前研究进展.云南大学学报(自然科学版), 2024, 46(5), 926-944.
[8] Ruixi Gao, Qi Huang, Yanfeng Zeng, Dandan Chen, Ziming Jia, Bingchen Han, Xianju Huang, Qiang Wang, Xin Hu, Maochuan Liao, Jun Li Pueraria lobata–Prunus mume Complex Alleviates Alcoholic Liver Disease by Regulating Lipid Metabolism and Inhibiting Inflammation: A Transcriptome and Gut Microbiota Analysis.Foods, 2024, 13(15), 2431.
[9] Xi Luo, Sen Li, Yuting Tian, Yuqi Tian, Limei Gao, Qiang Wang, Yongsheng Zheng Atroposelective Construction of Naphthylpyrazoles by Chiral Phosphoric Acid Catalyzed Enantioselective Cross-Coupling of Pyrazoles with Naphthoquinone Esters.European Journal of Organic Chemistry, 2024, 27(23), e202400254.
[10] Ruixi Gao, Bingchen Han, Yanfeng Zeng, Linchuang Shen, Xinqiao Liu, Qiang Wang, Maochuan Liao, Jun Li HPLC–DAD Analysis, SFE-CO2 Extraction, and Antibacterial Activity on Bioactive Compounds from Mosla chinensis Maxim..Molecules, 2023, 28(23), 7724.
[11] Yuting Tian, Dongqing He, Limei Gao, Yu Zou, Xiaoshuang Liu, Qiang Wang, Enxiang Liang, Yongsheng Zheng Regioselective Reaction of 2-Indolylmethanols with Enamides.Molecules, 2023, 28(8).
[12]邓憬童,周童曦,韩庆迪,程海涛,刘阳,王强,杨新洲 纤枝金丝桃中的一个新的多环多异戊烯基间苯三酚衍生物.药学学报, 2022, 57(9), 2767-2773.
[13] Limei Gao, Ruijie Shi, Yuting Tian, Xi Luo, Yongsheng Zheng, Qiang Wang Synthesis of Pyrazoles through [3+2] Cyclization of Nitrile Imines with Cinnamaldehydes Followed by Air Oxidation.ChemistrySelect, 2021, 6(45), 12838-12842.
[14] Jing Hu, Mengkang Gao, Yang Zhang, Yusui Wang, Zhenrui Qiao, Weiya Zhang, Qiang Wang, Lin Yan, Hai Qian Novel piperazine urea derivatives as highly potent transient receptor potential vanilloid 1 (TRPV1) antagonists.Bioorganic Chemistry, 2021, 115, 105229.
[15] Xiaoqin Zheng, Zi Wu, Jie Xu, Xinxin Zhang, Yijun Tu, Jiachuan Lei, Ruiying Yuan, Haitao Cheng, Qiang Wang, Jianqing Yu Bioactive sesquiterpenes from Inula helenium.Bioorganic Chemistry, 2021, 114, 105066.
[16] Jiajia Mou, Qiang Wang, Yanru Deng, Danghui Chen, Shuang Qiu Synthesis and structure confirmation of 7-ester-8-aminomethylene-substituted baicalein derivatives.Journal of the Chinese Chemical Society, 2021, 68(9), 1598-1603.
[17] Yun Huang, Tongxi Zhou, Yirui Zhang, Huiqi Huang, Yuanren Ma, Chaoqun Wu, Qiang Wang, Qinxiong Lin, Xinzhou Yang, Kejian Pang Antidiabetic activity of a Flavonoid-Rich extract from flowers of Wisteria sinensis in type 2 diabetic mice via activation of the IRS-1/PI3K/Akt/GLUT4 pathway.Journal of Functional Foods, 2021, 77.
[18] Yan Wang, Li Su, Qiang Wang, Li Zhang, Yepeng Luan Novel histone deacetylase inhibitors bearing a 4-piperidin-4-yl-triazole scaffold as antitumor agents.Drug Development Research, 2019, 81(1), 52-61.
[19] Qiang Wang, Qi Shi, Li Huang Novel Aminopeptidase N Inhibitors with Improved Antitumor Activities.Letters in Drug Design & Discovery, 2016, 13(1), 98-106.
[20] Huquan Gao, Wenqiang Guo, Qiang Wang, Lianqing Zhang, Meilin Zhu, Tianjiao Zhu, Qianqun Gu, Wei Wang, Dehai Li Aspulvinones from a Mangrove Rhizosphere Soil-derived Fungus Aspergillus terreus Gwq-48 with Anti-influenza A viral (H1N1) Activity.Bioorganic & Medicinal Chemistry Letters, 2013, 23, 1776-1778.
[21] Jing Su, Qiang Wang, Jinhong Feng, Cong Zhang, Deyu Zhu, Tiandi Wei, Wenfang Xu, Lichuan Gu Engineered Thermoplasma acidophilum factor F3 mimics human aminopeptidase N (APN) as a target for anticancer drug development.Bioorganic & Medicinal Chemistry, 2011, 19, 2991-2996.
[22] Qiang Wang, Fuming Xu, Jiajia Mou, Jian Zhang, Luqing Shang, Yepeng Luan, Yumei Yuan, Yingzi Liu, Minyong Li, Hao Fang, Binghe Wang, Wenfang Xu Design, synthesis and primary activity evaluation of novel L-lysine derivates as aminopeptidase N/CD13 inhibitors.Protein & Peptide Letters, 2010, 17, 847-853.
[23] Kanghui Yang, Qiang Wang, Li Su, Hao Fang, Xuejian Wang, Jianzhi Gong, Binghe Wang, Wenfang Xu Design and synthesis of novel chloramphenicol amine derivatives as potent aminopeptidase N (APN/CD13) inhibitors.Bioorganic & Medicinal Chemistry, 2009, 17, 3810-3817.
[24] Qiang Wang, Maoying Chen, Huawei Zhu, Jie Zhang, Hao Fang, Binghe Wang, Wenfang Xu Design, synthesis and QSAR studies of novel Lysine derives as aminopeptidase N/CD13 inhibitors.Bioorganic & Medicinal Chemistry, 2008, 16, 5473-5481.
[25] Jie Zhang, Qiang Wang, Hao Fang, Wenfang Xu, Ailin Liu, Guanhua Du Design, synthesis, inhibitory activity and SAR studies of hydrophobic p-aminosalicylic acid derivatives as neuraminidase inhibitors.Bioorganic & Medicinal Chemistry, 2008, 16, 3839-3847.
[26] Xian-Chao Cheng, Qiang Wang, Hao Fang, Wei Tang, Wen-Fang Xu Synthesis of new sulfonyl pyrrolidine derivatives as matrix metalloproteinase inhibitors.Bioorganic & Medicinal Chemistry, 2008, 16, 7932-7938.
[27] Xian-Chao Cheng, Qiang Wang, Hao Fang, Wei Tang, Wen-Fang Xu Design, synthesis and evaluation of novel sulfonyl pyrrolidine derivatives as matrix metalloproteinase inhibitors.Bioorganic & Medicinal Chemistry, 2008, 16, 5398-5404.
[28] Luqing Shang, Qiang Wang, Hao Fang, Jiajia Mu, Xuejian Wang, Yumei Yuan, Binghe Wang, Wenfang Xu Novel 3-phenylpropane-1,2-diamine derivates as inhibitors of aminopeptidase N (APN).Bioorganic & Medicinal Chemistry, 2008, 16, 9984-9990.
[29] Xian-Chao Cheng, Qiang Wang, Hao Fang, Wei Tang, Wen-Fang Xu Design, synthesis and preliminary evaluation of novel pyrrolidine derivatives as matrix metalloproteinase inhibitors.European Journal of Medicinal Chemistry, 2008, 43, 2130-2139.
[30] Xian-Chao Cheng, Qiang Wang, Hao Fang, Wen-Fang Xu Role of Sulfonamide Group in Matrix Metalloproteinase Inhibitors.Current Medicinal Chemistry, 2008, 15, 368-373.
[31] Xian-Chao Cheng, Qiang Wang, Hao Fang, Wen-Fang Xu Advances in Matrix Metalloproteinase Inhibitors Based on Pyrrolidine Scaffold.Current Medicinal Chemistry, 2008, 15, 374-385.
[32] Jie Jiao, Qiang Wang, Huawei Zhu, Hao Fang, Wenfang Xu Synthesis and biological evaluation of a new series of histone deacetylases inhibitors.Chinese Chemical Letters, 2008, 19, 673-675.
[33] Jie Zhang, Qiang Wang, Hao Fang, Wenfang Xu, Ailin Liu, Guanhua Du Design, synthesis, inhibitory activity, and SAR studies of pyrrolidine derivatives as neuraminidase inhibitors.Bioorganic & Medicinal Chemistry, 2007, 15, 2749-2758.
