民族：汉族
职称：副教授/硕士研究生导师
学科专业：药物化学/药理学
研究方向：基于天然多糖及其结构片段的创新药物研发
电子邮箱：gn2008.happy@163.com
工作及教育经历：
2026.1-至今，beat365官网，药学院，副教授/硕士研究生导师
2016.8-2025.12，beat365官网，药学院，讲师/硕士研究生导师
2013.9-2016.7，中国科学院昆明植物研究所，药物化学，博士
2012.7-2013.9，中国科学院昆明植物研究所，植物化学与西部植物资源持续利用国家重点实验室，人才助手
2009.9-2012.6，中南大学，生药学，硕士
2005.9-2009.7，济宁医学院，药物制剂，学士
研究领域：
主要从事天然产物糖化学及药理学研究，包括糖类活性成分化学、结构修饰、活性筛选及靶点机制研究。
以第一作者或通讯作者（含共同通讯）在Carbohydr Polym、Eur J Med Chem、Int J Biol Macromol、Thromb Haemost、Arterioscl Throm Vas等国际期刊发表学术论文三十余篇；作为主要发明人申请并获得中国、美国、日本等国内外授权专利三十余项。
作为核心骨干参加了新靶点抗凝药物LFG53/YB209（内源性凝血因子X酶抑制剂）研发，主要承担药物原料及制剂制备工艺、新药目标成分确认、质量研究、结构确证、杂质研究，并参与构-效关系研究及药代动力学研究、知识产权保护与新药注册等工作。LFG53/YB209已作为First-in-class类新药取得中国NMPA和美国FDA的临床批件，已完成临床I期试验。目前，重点开展基于寡糖结构片段的新药研发。
主要荣誉与获奖：
1.云南省科学技术奖技术发明一等奖（2024，第二完成人）
2.云南省专利奖二等奖（2024，第三完成人）
3.优秀班导师（2025）
4.优秀学士学位论文指导教师（2026）
5.优秀学士学位论文指导教师（2025）
教学工作：
主要承担《药事管理学》、《药物分析I》理论课及《药物化学》、《生物化学》、《天然药物化学》等实验课。指导“大学生创新训练计划”国家级1项，省级2项，校级2项。
主持或参加的科研项目：
[1]国家自然科学基金青年项目（81703374），主持
[2]湖北省自然科学基金面上项目（2025AFB787），主持
[3]中央高校基本科研业务项目（CZQ23025），主持
[3]国家自然科学基金面上项目（82574407），骨干成员
[4]国家自然科学基金面上项目（82073725），骨干成员
[5]云南省重大科技专项计划项目（202602AS100013），骨干成员
代表性论文：
[1]WangP#,GaoN#,*,MaoQJ#, ZhouLT, WangY, Ying PanY, WuFY, KangPH, MinZY, MaYJ, SunHF, ShiX, YangMY, LiFC*, ZhangYY*, ZhaoJH*.A heparan-like glycosaminoglycan from the white jade snail: Precise structural elucidation, alkaline-induced artificial changes, and non-anticoagulant heparanase inhibition.CarbohydratePolymers,2026(Accepted).
[2]LiSJ, LinLS, YangL, PanY, GaoN, YinRH*, ZengCY*,ZhaoJH.P-selectin inhibition and the structure-activity relationship of sea cucumber-derived fucosylated glycosaminoglycan oligosaccharides.MarineDrugs,2026, 24(5):177.
[3]Sun JY, Sha L, Zhu GY, Li LQ, Li PF, Chen MR, Wang JH, Jiao XY,Gao N*, Zhao JH*. Persulfate-driven free radical depolymerization of fucosylated chondroitin sulfate and intrinsic Xase inhibition of the resulting oligosaccharides.CarbohydrateResearch,2026, 563: 109844.
[4]Xiao C#, Xu L#, Cai Y, Liu ZH, Li YN,Gao N*, Zhao JH*. High molecular weight fucosylated glycosaminoglycan promotes the binding of antithrombin and thrombin: a template mechanism and structure-activity relationship study.Glycoconjugate Journal,2025, 43(1): 2.
[5]LiCY, SunHF, GuX, LongW, ZhuGY, WuXL, WangY, LiPF, ShaL, ZhangJL, SunWW*,GaoN*,ZuoZL, ZhaoJH*. Exploring the inhibitory effects of fucosylated chondroitin sulfate (FCS) oligosaccharide isolated fromStichopus horrensand the derivatives on P-selectin.MarineDrugs,2025, 23(6): 236.
[6]XuC, ShiX, SunHF, YuLJ, ZhangL, LanD, WuXL, ChenMR, ChengNQ, PanY, HeJY, YinRH, ZhouLT*,GaoN*, ZhaoJH. Unique structure and biological properties of fucosylated glycosaminoglycan and its oligosaccharides from sea cucumberHolothuria floridana.CarbohydratePolymers, 2025, 355:123351.
[7]SunHF#, ZhuGY#, LiSJ, LiPF, ZhangJL, YinRH, YuanL,GaoN*,ZhaoJH*. Fucosylated glycosaminoglycan oligosaccharideHS14, derived from sea cucumbers, is a novel inhibitor of platelet toll-like receptor 2.Marine Drugs,2025; 23: 110.
[8]ChengNQ#,GaoN#,*, WangP#, MaYJ, LiPF, WuXL, SunJY, DaiYL, ZhaoJH*. Structure identification and biological activity of a novel sulfated glycosaminoglycan-like polysaccharide fromSepia recurvirostraink.CarbohydratePolymers, 2025, 357:123415.
[9]Zhang TC, Lin LS, Ren L, Sun HF, Wang WL, Liu S, Li SN, Xiao C,Gao N*, Zhao JH. Structure and pharmacokinetics/pharmacodynamics of the anticoagulant tetradecasaccharide oHG-14 as an intrinsic tenase inhibitor.Thrombosis Research, 2024, 240: 109041.
[10]Ma Y, Zuo ZC, Zheng WQ, Yin RH, Wu XW, Ma YJ, Ji MC, Ma WW, Li X*, Xiao WL*,Gao N*, Zhao JH. Structural characterization of a distinct fucan sulfate fromPattalus mollisthrough an oligosaccharide mapping approach.CarbohydrateResearch, 2024,536:109052.
[11]Li SJ, Wang WL, Lin LS, Yang L, Cai Y, Yang XZ, Zhang TC, Xiao C, Yan H,Gao N*, Zhao JH*. Oligosaccharide blocks PAR1 (proteinase-activated receptor 1)-PAR4–mediated platelet activation by binding to thrombin exosite II and impairs thrombosis.Arteriosclerosis, Thrombosis, and Vascular Biology, 2023, 43: 253-266.
[12]Chen R, Wang WL, Yin RH, Pan Y, Xu C,Gao N*, Luo XD*, Zhao JH*.Structural Characterization andanticoagulant activities of a keratan sulfate-like polysaccharide from the sea cucumberHolothuria fuscopunctata.MarineDrugs,2023, 21:632.
[13]Sun HF, Yang SS, Li PF, Shang XL, Wang P, Zhang JL, Yuan L, Yin RH,Gao N*, Zhao JH*. Comparative assessment of APTT reagents for evaluating anticoagulant sensitivity of fucosylated glycosaminoglycans (FGs) derived from sea cucumbers.Marine Drugs, 2023, 21, 568.
[14]Lan D, Zhang JL, Shang XL, Yu LJ, Xu C, Wang P, Cui LG, Cheng NQ, Sun HF, Ran JN, Sha L, Yin RH,Gao N*, Zhao JH*.Branch distribution pattern and anticoagulant activity of a fucosylated chondroitin sulfate fromPhyllophorella kohkutiensis.Carbohydrate Polymers, 2023, 321: 121304.
[15]Zuo ZC, He ZC, Ma Y, Xu C, Tao XL, Ning ZM, Gao L, Ailainuer R,Gao N*, Zhao JH*. Structure characterization of a highly branched galactan from the slugVaginulus alteand its utilization by human gut microbiota.International Journal of Biological Macromolecules, 2023, 236: 123935.
[16]Tao XL, Wang WL, Shi X, Lan D, Mao H, Ning ZM, Gao L, Zuo ZC, Xu C, Yang ZQ, Wang Y, Zuo ZL*,Gao N*, Zhao JH*. Peroxidative depolymerization of fucosylated glycosaminoglycan: Bond-cleavage pattern and activities of oligosaccharides.Carbohydrate Polymers, 2022, 295: 119855.
[17]Gao L, Xu C, Tao XL, Zuo ZC, Ning ZM, Wang LH,Gao N*, Zhao JH*. Structure elucidation of fucan sulfate from sea cucumberHolothuria fuscopunctatathrough a bottom up strategy and the antioxidant activity analysis.International Journal of Molecular Sciences, 2022, 23(9): 4488.
[18]Ning ZM, Wang P, Zuo ZC, Tao XL, Gao L, Xu C, Wang ZY, Wu B*,Gao N*, Zhao JH. A fucan sulfate with pentasaccharide repeating units from the sea cucumberHolothuria floridanaand its anticoagulant activity.Marine Drugs, 2022, 20(6): 377.
[19]Liu XX, Ning ZM, Zuo ZC, Wang Pin, Yin RH,Gao N*, Wu B, Zhao JH. The glycosidic bond cleavage and desulfation investigation of fucosylated glycosaminoglycan during mild acid hydrolysis through structural analysis of the resulting oligosaccharides.Carbohydrate Research, 2022, 511: 108493.
[20]Chen R, Yin RH, Li SN, Pan Y, Mao H, Cai Y, Lin LS, Wang WL, Zhang TC, Zhou LT,Gao N*, Luo XD*, Zhao JH*. Structural characterization of oligosaccharides from free radical depolymerized fucosylated glycosaminoglycan and suggested mechanism of depolymerization.Carbohydrate Polymers, 2021, 270: 118368.
[21]Shi X#, Guan R#, Zhou LT, Zuo ZC, Tao XL, Wang P, Zhou YR, Yin RH, Zhao LY*,Gao N*,Zhao JH.Structural characterization and heparanase inhibitory activity of fucosylated glycosaminoglycan fromHolothuria floridana.Marine Drugs, 2021, 19: 162.
[22]Liu XX, Zhang ZX, Mao H, Wang P, Zuo ZC, Gao L, Shi X, Yin RH,Gao N*, Zhao JH*. Characterization of the hydrolysis kinetics of fucosylated glycosaminoglycan in mild acid and structure of the resulting oligosaccharides.Marine Drugs, 2020, 18: 286.
[23]Sun HF#,GaoN#, Ren L, Liu S, Lin LS, Zheng WQ, Zhou LT, Yin RH, Zhao JH*.The components and activities analysis of a novel anticoagulant candidate dHG-5.European Journal of Medicinal Chemistry, 2020, 207: 112796.
[24]Gao N, Chen R, Mou RR, Xiang JY, Zhou K, Li Z, Zhao JH*. Purification, structural characterization and anticoagulant activities of four sulfated polysaccharides from sea cucumberHolothuria fuscopunctata.International Journal of Biological Macromolecules, 2020, 164: 3421-3428.
[25]CaiY#, Yang WJ#, Li XM, Zhou LT, Wang ZJ, Lin LS, Chen DY, Zhao LY, Li ZK. Liu SB, Yin RH *, Zuo ZL *,Gao N*, Zhao JH. Precise structures and anti-intrinsic tenase complex activity of three fucosylated glycosaminoglycans and their fragments.Carbohydrate Polymers, 2019, 224: 115-146.
[26]Guan RW#, Peng Y, Zhou LT, Zheng WQ, Liu XX, Wang P, Yuan QX,Gao N*, Zhao LY*, Zhao JH*. Precise structure and anticoagulant activity of fucosylated glycosaminoglycan fromApostichopus japonicus: analysis of its depolymerized fragments.Marine Drugs, 2019, 17: 195.
[27]Zhou LT#,Gao N#, Sun HF, Xiao C, Yang L, Lin LS, Yin GH, Li Z, Zhang HB*, Ji X*, Zhao JH*. Effects of native fucosylated glycosaminoglycan, its depolymerized derivatives on intrinsic factor Xase, coagulation, thrombosis, and hemorrhagic risk.Thrombosis and Haemostasis, 2020, 120(4): 607-619.
[28]Yang WJ#, Chen DY#, He ZC, Zhou LT, Cai Y, Mao H,Gao N*, Zuo ZL*, Yin RH*, Zhao JH. NMR characterization and anticoagulant activity of the oligosaccharides from the fucosylated glycosaminoglycan isolated fromHolothuria coluber.Carbohydrate Polymers, 2020, 233: 115844.
[29]Xu L#,Gao N#, Xiao C, Lin LS, Purcell SW, Wu MY*, Zhao JH*. Modulating the degree of fucosylation of fucosylated chondroitin sulfate enhances heparin cofactor II-dependent thrombin inhibition.European Journal of Medicinal Chemistry, 2018, 154: 133-143.
[30]Shang FN#,Gao N#, Yin RH, Lin LS, Xiao C, Zhou LT, Li Z, Purcell SW, Wu MY*, Zhao JH*. Precise structures of fucosylated glycosaminoglycan and its oligosaccharides as novel intrinsic factor Xase inhibitors.European Journal of Medicinal Chemistry, 2018, 148: 423-435.
[31]Gao N#, Lu F#, Xiao C, Yang L, Chen J, Zhou K, Wen DD, Li Z, Wu MY, Jiang JM, Liu GM*, Zhao JH*. β-Eliminative depolymerization of the fucosylated chondroitin sulfate and anticoagulant activities of resulting fragments.Carbohydrate Polymers, 2015, 127(3): 427-437.
[32]Gao N, Wu MY, Liu S, Lian W, Li Z, Zhao JH*. Preparation and characterization of O-acylated fucosylated chondroitin sulfate from sea cucumber.Marine Drugs, 2012, 10: 1647-1661.
