个人信息：
姓名：尹荣华
出生年月：1990-10
民族：汉
职称：副教授(博士研究生导师)
学科专业：药物化学
电子邮箱：yinrh77@163.com
教育及工作经历：
2025.4—至今，beat365官网药学院，副教授，硕士生导师/博士生导师
2020.9—2025.4，beat365官网药学院，讲师，硕士生导师
2019.1—2020.9，中国科学院昆明植物研究所，助理研究员
2015.9—2019.1，中国科学院昆明植物研究所，理学博士
2012.9—2015.6，中国科学院昆明植物研究所，理学硕士
2008.9—2012.6，四川农业大学，农学学士
研究方向：
天然产物糖化学及基于结构片段的活性评价与新药研发
科研项目：
1.FG侧链结构多样性及其在强效P-选择素抑制剂设计中的应用研究，国家自然科学基金面上项目，2025.1-2028.12，50万，主持；
2.玉足海参糖胺聚糖的化学结构与抗凝抗血栓作用特点研究，武汉市自然科学基金探索计划(晨光计划)，2025.6-2027.5，10万，主持；
3.新靶点抗凝药物FG-11衍生物的设计与成药性研究，湖北省自然科学基金面上项目，2024.3-2026.3，5万，主持；
4.二糖侧链FG的确切结构特征及其对FXase抑制活性的影响研究，国家自然科学基金青年基金项目，2020.1-2022.12年，25万，主持；
5.Ludwigothurea grisea来源糖胺聚糖的结构澄清及抗凝构效关系分析，中央高校基本科研业务费青年项目，2021.4-2023.4，5万，主持；
6.FG-8mer抑制内源性因子X酶的分子机制及其机制相关的抗凝活性特征，国家自然科学基金面上项目，2018.1-2021.12，56万，参加；
7.内源性F.Xase抑制剂LFG-53新药临床前研究，中国科学院药物创新研究院自主部署科研项目，2015.9-2017.8，192.5万，参加。
代表性论文：
1.Ying Hong, Ying Pan, Guangyu Zhu, Jing Wen, Rou Chen, Lige Cui, Huilin Chen, Tong Wu, Ronghua Yin*, Jinhua Zhao. Structure characterization and multi-target inhibitory activities of fucosylated chondroitin sulfate from sea cucumberThelenota anax.CarbohydratePolymers,2026; 388: 125591.
2.Shengtao Yang#,Ying Pan#,Wenwen Ma,HaoZeng,NaGao,WenwuSun,RonghuaYin*,JinghuaZhao.Unveiling and suppressing side reactions in the deacetylation and deaminative depolymerization of fucosylated chondroitin sulfate for enhanced oligosaccharide preparation.CarbohydratePolymers,2026; 385: 125402.
3.Linxia Chen#, Dilihumaer Ruzemaimaiti#, Lige Cui#, Guangyu Zhu, Jiali Zhang, Huifang Sun, Yan Ma, Ying Hong, Na Gao, Lina Nong, Wenxin Ma, Qinjie Qin, Ronghua Yin*, Jinhua Zhao*. Chemical structure and P-selectin inhibition of two linear and highly regular homofucans from the brown algaFucus vesiculosus.CarbohydratePolymers, 2026, 381:125228.
4.Yan Ma#, Ying Pan#, Lutan Zhou#, Lige Cui, Xuewen Wu, Mengchen Ji, Dilihumaer Ruzemaimaiti, Wenwen Ma, Haitian Wang, Linxia Chen, Weilie Xiao*, Ronghua Yin*, Jinhua Zhao*. Characterization and biological activities of a high-yield galactosylated heparan sulfate from Bursatella leachii egg strings.CarbohydratePolymers, 2026, 375:124760.
5.Ying Pan, Huifang Sun, Xi Gu, Sujuan Li, Shengtao Yang, Liang Zhang, Hui Mao, Pin Wang, Shasha Yang, Ronghua Yin*, Zhili Zuo*, Jinhua Zhao*. Oligosaccharide-assisted resolution of holothurian fucosylated chondroitin sulfate for fine structure and P-selectin inhibition.CarbohydratePolymers,2025, 351: 123145.
6.Lige Cui, Huifang Sun, Xiaolei Shang, Jing Wen, Pengfei Li, Shengtao Yang, Linxia Chen, Xiangyang Huang, Haoyang Li,Ronghua Yin*, and Jinhua Zhao. Purification andstructural analyses of sulfated polysaccharides from low-value sea cucumberStichopus nasoand anticoagulant activities of its oligosaccharides.MarineDrugs. 2024; 22:265.
7.DilihumaerRuzemaimaiti#, HuifangSun#, JialiZhang, ChenXu, LinxiaChen,Ronghua Yin*, JinhuaZhao*. Oligomer-guided recognition of two fucan sulfate fromBohadschia argusand inhibition of P-selectin binding to its ligand.CarbohydratePolymers, 2023, 317:121080.
8.RonghuaYin, YingPan, YingCai, FanYang, NaGao, DilihumaerRuzemaimaiti, JinhuaZhao*. Re-understanding of structure and anticoagulation: Fucosylated chondroitin sulfate from sea cucumberLudwigothurea grisea.CarbohydratePolymers.2022, 294: 119826.
9.Weili Wang#, Hui Mao#, Sujuan Li, Longlong Zhang, Lian Yang,Ronghua Yin*, Jinhua Zhao*. Branchedchondroitinsulfateoligosaccharidesderived from theseacucumberAcaudina molpadioidesstimulateneuriteoutgrowth.MarineDrugs. 2022; 20: 653.
10.Xiaomei Li, Huifang Sun, Zimo Ning, Wenjiao Yang, Ying Cai,Ronghua Yin*, Jinhua Zhao*. Mild acid hydrolysis on Fucan sulfate fromStichopus herrmanni: Structures, depolymerization mechanism and anticoagulant activity.Food Chemistry. 2022, 395: 133559.
11.RonghuaYin, LutanZhou, NaGao, LishaLin, HuifangSun, DingyuanChen, YingCai, ZhiliZuo, KaifengHu, ShengxiongHuang*,JikaiLiu*, JinhuaZhao*. Unveiling the disaccharide-branched glycosaminoglycan and anticoagulant potential of its derivatives.Biomacromolecules2021,22:1244-1255.
12.YanMa, NaGao, ZhichuangZuo, ShanniLi, WengqiZheng, XiangShi, QipeiLiu, TingMa,RonghuaYin*, XianLi *, JinhuaZhao *. Five distinct fucan sulfates from sea cucumberPattalus mollis: Purification, structural characterization and anticoagulant activities.International Journal of BiologicalMacromolecules2021; 186: 535–543.
13.ShanniLi, WeiZhong, YingPan, LishaLin, YingCai, HuiMao, TaocuiZhang, SujuanLi, RuChen, LutanZhou, WeiliWang, QinghuaCui *,RonghuaYin*, ShengxiongHuang*, JinhuaZhao*. Structural characterization and anticoagulant analysis of the novel branched fucosylated glycosaminoglycan from sea cucumberHolothuria nobilis.CarbohydratePolymers.2021, 269: 118290.
14.XiaomeiLi, ShanniLi, JieLiu, LishaLin, HuifangSun, WenjiaoYang, YingCai, NaGao, LutanZhou, HongboQin*,RonghuaYin*, JinhuaZhao*. A regular fucan sulfate fromStichopus herrmanniand its peroxide depolymerization: Structure and anticoagulant activity.CarbohydratePolymers.2021, 256: 117513.
15.LutanZhou,RonghuaYin, NaGao, HuifangSun, DingyuanChen, YingCai, LinRen, LianYang, ZhiliZuo*, HongbinZhang*, JinhuaZhao*. Oligosaccharides from fucosylated glycosaminoglycan prevent breast cancer metastasis in mice by inhibiting heparanase activity and angiogenesis.PharmacologicalResearch.2021,166: 105527
16.HuiMao1, Ying Cai1, Shanni Li, Huifang Sun, Lisha Lin, Ying Pan, Wenjiao Yang, Zhicheng He, Ru Chen, Lutan Zhou, Weili Wang,Ronghua Yin*, Jinhua Zhao*. A new fucosylated glycosaminoglycan containing disaccharide branches fromAcaudina molpadioides: Unusual structure and anti-intrinsic tenase activity.Carbohydrate Polymers.2020; 245: 116503.
17.Wenjiao Yang1, Dingyuan Chen1, Zhicheng He, Lutan Zhou, Ying Cai, Hui Mao, Na Gao*, Zhili Zuo*,Ronghua Yin*, Jinhua Zhao. NMR characterization and anticoagulant activity of the oligosaccharides from the fucosylated glycosaminoglycan isolated fromHolothuria coluber.Carbohydrate Polymers.2020; 233: 115844.
18.Ying Cai1, Wenjiao Yang1, Xiaomei Li, Lutan Zhou, Zhongjuan Wang, Lisha Lin, Dingyuan Chen, Longyan Zhao, Zhongkun Li, Shubai Liu,Ronghua Yin*, Zhili Zuo*, Na Gao*, Jinhua Zhao, Precise structures and anti-intrinsic tenase complex activity of three fucosylated glycosaminoglycans and their fragments,Carbohydrate Polymers.2019, 224:115146.
19.Zhicheng He, Lutan Zhou, Lisha Lin,Ronghua Yin*, Jinhua Zhao*, Structure and heparanase inhibitory activity of a new glycosaminoglycan from the slugLimacus flavus,Carbohydrate Polymers.2019, 220:176-184.
20.Wenqi Zheng, Lutan Zhou, Lisha Lin, Ying Cai, Huifang Sun, Longyan Zhao, Na Gao,Ronghua Yin* Jinhua Zhao*, Physicochemical characteristics and anticoagulant activities of the polysaccharides from sea cucumberPattalus mollis,Marine Drugs.2019, 17:198.
21.Ronghua Yin, Lutan Zhou, Na Gao, Zi Li, Longyan Zhao, Feineng Shang, Mingyi Wu*, Jinhua Zhao*, Oligosaccharides from depolymerized fucosylated glycosaminoglycan: structures and minimum size for intrinsic factor Xase complex inhibition,Journal of Biological Chemistry. 2018, 293:14089-14099.
22.Feineng Shang1, Na Gao1,Ronghua Yin, Lisha Lin, Chuang Xiao, Lutan Zhou, Zi Li, Steven W. Purcell, Mingyi Wu*, Jinhua Zhao*, Precise structures of fucosylated glycosaminoglycan and its oligosaccharides as novel intrinsic factor Xase inhibitors,European Journal of Medicinal Chemistry.2018, 148: 423-435.
23.Wenjiao Yang, Ying Cai,Ronghua Yin, Lisha Lin, Zhongkun Li*, Mingyi Wu*, Jinhua Zhao*, Structural analysis and anticoagulant activities of two sulfated polysaccharides from the sea cucumberHolothuria coluber,International Journal of Biological Macromolecules. 2018, 115: 1055-1062.
24.Ying Cai, Wenjiao Yang,Ronghua Yin, Lutan Zhou, Zhongkun Li*, Mingyi Wu*, Jinhua Zhao*, An anticoagulant fucan sulfate with hexasaccharide repeating units from the sea cucumberHolothuria albiventer,Carbohydrate Research.2018, 464:12-18.
25.Lisha Lin, Longyan Zhao, Na Gao,Ronghua Yin, Sujuan Li, Huifang Sun, Lutan Zhou, Guiling Zhao, Steven W. Purcell, Jinhua Zhao*, From multi-target anticoagulants to DOACs, and intrinsic coagulation factor inhibitors,Blood Reviews.2020, 39:100615.
26.Ronghua Yin, Xue Bai, Tao Feng, Zejun Dong, Zhenghui Li*, and Jikai Liu*, Two new compounds fromXanthium strumarium,Journal of Asian Natural Products Research. 2016, 18: 354-359.
27.Ronghua Yin, Zhenzhu Zhao, Xu Ji, Zejun Dong, Zhenghui Li, Tao Feng*, Jikai Liu*, Steroids and sesquiterpenes from cultures of the fungusPhellinus igniarius,Natural Products and Bioprospecting. 2015, 5:17-22.
28.Ronghua Yin, Zhenzhu Zhao, Heping Chen, Xia Yin, Xu Ji, Zejun Dong, Zhenghui Li, Tao Feng*, Jikai Liu*, Tremulane sesquiterpenes from cultures of the fungusPhellinus igniariusand their vascular-relaxing activities,Phytochemistry Letters.2014, 10:300-303.
29.Heping Chen, Zhenzhu Zhao,Ronghua Yin, Xia Yin, Tao Feng, Zhenghui Li, Kun Wei, Jikai Liu, Six new vibralactone derivatives from cultures of the fungusBoreostereum vibrans,Natural Products and Bioprospecting.2014, 4:271-276.
30.Dongbao Hu, Wenxin Li, Zhenzhu Zhao, Tao Feng,Ronghua Yin, Zhenghui Li, Jikai Liu*, Huajie Zhu*, Highly unsaturated pyranone derivatives from the basidiomyceteJunghuhnianitida,Tetrahedron Letters.2014, 55:6530-6533.
31.Jiangbo He, Xiaoman Lv, Zhenghui Li, Shen Zhang, Dongbao Hu,Ronghua Yin, Zhenzhu Zhao, Tao Feng*, Jikai Liu*, Chain terpenoids isolated from cultures of basidiomycetePhellinus sp.Journal of Asian Natural Products Research.2015, 17:1-5.
